主要从事抗菌肽的药物化学和生物化学研究、基于多肽的抗菌创新药物发现(抗菌肽药物分子设计、合成及抗菌肽抗肿瘤、抗菌、抗真菌活性、作用机制及构效关系研究)和基于多肽的生物医学材料研究。

主持项目：

1. 国家自然科学基金面上项目, “基于环肽抗生素lugdunin的全新抗菌多肽的设计、合成及抗菌活性研究”， (No. 82073679) 2021.1-2014.12. 在研；

2. 甘肃省自然科学基金一般项目，“基于“侧链微修饰“策略的高稳定抗菌肽构建及抗菌作用、构效关系研究”，（No. 20JR5RA245）2020.11-2022.10. 在研；

3. 中央高校基本科研业务费专项资金自由探索项目“超短序列抗菌肽Jelleine-1抗真菌活性、作用机制及构效关系研究”，（lzujbky-2017-128）2017.1-2018.12；已结题；

4. 教育部“春晖计划”合作科研项目“赖氨酸侧链修饰的抗菌肽protonectin衍生物的稳定性、抗菌活性及作用机制研究”，（Z2016002），2016.12-2018.12；已结题；

5. 国家自然科学基金面上项“化学修饰策略构建高稳定性抗菌肽polybia-CP衍生物及其抗真菌活性研究”（No. 81573265）, 2016.1-2017.12；已结题；

6. 中央高校基本科研业务费专项资金自由探索项目“具临床应用潜力的限制性结构抗菌肽polybia-CP衍生物的设计、合成及抗真菌活性研究”（lzujbky-2015-155），2015.1-2016.6；已结题；

7. 中央高校基本科研业务费专项资金自由探索项目“赖氨酸侧链修饰的抗菌肽protonectin衍生物的稳定性、抗菌活性及作用机制研究” （lzujbky-2015-279），2015.7-2016.12；已结题；

8. 我校中央高校自由探索面上项目“新型抗菌肽氟代衍生物抗真菌活性、作用机制及构效关系研究”(No.lzujbky-2013-164)，2013.1-2014.6；已结题；

9. 国家自然科学基金青年基金项目“以细胞膜为靶标的新型抗菌肽polybia-MPI类似物的设计、合成及抗菌活性研究”（No.31200584）, 2013.01-2015.12；已结题；

10. 教育部博士点新教师基金项目“抗菌肽polybia-MPI 的新型类似物的设计合成、抗菌活性及构效关系研究”（No.20120211120045）， 2013.1-2015.12；已结题；

11. 教育部“春晖计划”合作科研项目“抗菌肽优化设计合成、构效关系及膜-肽作用分子动力学机制研究”（No.Z2010082）， 2011.7—2013.7；已结题；

12. 我校中央高校自由探索面上项目“免疫蛋白NK-lysin衍生的抗菌肽在耐药病菌、流感病毒感染治疗中的应用研究”(No.lzujbky-2010-129)，2010.7-2011.7；已结题；

已发表论文目录（第一作者和通讯作者）:

1. Zhang H, Wu Z, Zhou J, Wang Z, Yang C, Wang P, Fareed MS, He Y, Su J, Cha R*, Wang Kairong*. The Antimicrobial, Hemostatic, and Anti-Adhesion Effects of a Peptide Hydrogel Constructed by the All-d-Enantiomer of Antimicrobial Peptide Jelleine- Advanced Healthcare Materials. 2023:e2301612. doi: 10.1002/adhm.202301612. (IF2022  10.0)

2. Zhou J; Cha R*; Wu Z; Zhang C; He Y; Zhang H; Liu K; Fareed MS; Wang Z; Yang C; Zhang Y; Yan W*; Wang Kairong*; An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects, Nano Today, 2023, 49: 101801. (IF2021 18.962)

3. Teng P*, Shao H, Huang B, Xie J, Cui S*, Wang Kairong*, Cai J*. Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance. J. Med. Chem., 2023;66:2211-34. (IF2021 8.039)

4. Zhou J, Wang Z, Yang C, Zhang H, Fareed MS, He Y, Su J, Wang P, Shen Z, Yan Wenjin*, Wang Kairong*. A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing. Acta Biomater. 2022, 151: 223-234. (IF2021 10.633)

5. Zhou J, Zhang H, Fareed MS, He Y, Lu Y, Yang C, Wang Z, Su J, Wang P, Yan W*, Wang Kairong*. An Injectable Peptide Hydrogel Constructed of Natural Antimicrobial Peptide J-1 and ADP Shows Anti-Infection, Hemostasis, and Antiadhesion Efficacy. ACS Nano. 2022;16(5): 7636-7650. （IF2021 18.027）

6. Liang X, Liu K, Zhao P, Zhou J, Zhang F, He Y, Zhang H, Fareed MS, Lu Y, Xu Y, Zhang Z, Yan W*, Wang Kairong*. The effects of incorporation of the counterparts and mimics of L-lysine on the antimicrobial activity, hemolytic activity, cytotoxicity and tryptic stability of antimicrobial peptide polybia-MPII. Amino Acids. 2022;54(1):123-135.

7. Chen Q, Yang C, Xie Y, Wang Y, Li X*, Wang Kairong*, Huang J*, Yan W*. GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences. J Chem Inf Model. 2022;23;62(10): 2617- 2629. (IF2021 6.162)

8. H Sheng, J Zhou, B Li, Y He, X Zhang, J Liang, J Zhou, Q Su, E Xie, Wei Lan*, Kairong Wang*, Cunjiang Yu*. A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body. Science Advance 2021;7(2):eabe3097. （IF2021 14.957）

9. Zhou J, Zhang L, He Y, Liu K, Zhang F, Zhang H, Lu Y, Yang C, Wang Z, Fareed MS, Liang X*, Yan W*, Wang Kairong*. An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. Eur J Med Chem. 2021;219:113433. （IF2021 7.088）

10. Y Deng, Z Dong, F Gao, Y Guo, M Sun, Y Li, Y Wang, Q Chen, Kairong Wang, W Yan. The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction. J Org Chem. 2021;86(18):13011-13024.

11. F Gao, B Li, Y Wang, Q Chen, Y Li, Kairong Wang*, Wenjin Yan*. Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group. Org. Chem. Front., 2021;8, 2799-2819. (IF2021 5.456)

12. Jia F, Wang J, Zhang L, Zhou J, He Y, Lu Y, Liu K, Yan W*, Wang Kairong*. Multiple action mechanism and in vivo antimicrobial efficacy of antimicrobial peptide Jelleine-I. J Pept Sci. 2021;27(3):e3294.

13. Peng J, Qiu S, Jia F, Zhang L, He Y, Zhang F, Sun M, Deng Y, Guo Y, Xu Z, Liang X, Yan W*, Wang Kairong*. The introduction of L-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria. Amino Acids. 2021;53(1):23-32.

14. F Jia, X Liang, J Wang, L Zhang, J Zhou, Y He, F Zhang, Wenjin Yan* Kairong Wang*. Tryptic Stability and Antimicrobial Activity of the Derivatives of Polybia‑CP with Fine‑Tuning Modification in the Side Chain of Lysine. Int J Pept Res Ther., 2021, 27(2):1-12.

15. Peng J, Yang Y, Zhao P, Qiu S, Jia F, Wang J, Liang X, Chaudhry AS, Xu P, Yan W, Xu Z*, Wang K*. Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. Acta Biochim Biophys Sin (Shanghai). 2020;52(6):603-611.

16. B Li, F Gao, X Feng, M Sun, Y Guo, D Wen, Y Deng, J Huang, Kairong Wang*, Wenjin Yan*. Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition. Org. Chem. Front., 2019,6, 1567-1571. (IF2021 5.456)

17. Li B, Liu J, Gao F, Sun M, Guo Y, Zhou Y, Wen D, Deng Y, Chen H, Wang K, Yan W. The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition. Org Biomol Chem. 2019;17(11):2892-2895.

18. Wang C, Wen D, Chen H, Deng Y, Liu X, Liu X, Wang L, Gao F, Guo Y, Sun M, Wang Kairong*, Yan W*. The catalytic asymmetric synthesis of CF3-containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition. Org Biomol Chem. 2019;17(22):5514-5519.

19. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, w Yan*, R Wang*. The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species. Amino Acids. 2018;50(2):229-239.

20. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, W Yan*, R Wang*. D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. Acta Biochim Biophys Sin. 2017;49(10):916-925.

21. Q Shuai, R Zhu, Y Zhao, X An, F Jia, J Peng, Z Ma, Y Zhu, J Wang, J Su, Q Wang, H Wan, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of protonectin with D-amino acid substitutions, J Pept Sci., 2017; 23(5):392-402.

22. Z Dong, Y Zhu, B Li, C Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*, Asymmetric Synthesis of #-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction. J Org Chem., 2017; 2017;82(7):3482-3490. 

23. Y Zhao, M Zhang, S Qiu, J Wang, J Peng, P Zhao, R Zhu, H Wang, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI. AMB Express, 2016; 6(1):122.

24. J Su, Z Ma, X Li, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*，Asymmetric Synthesis of 2′-Trifluoromethylated Spiro-pyrrolidine-3,3′-oxindoles viaSquaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition. Advanced Synthesis & Catalysis, 2016;358:3777-3785. (IF2021 5.981)

25. Y Zhu, Z Dong，X Cheng, X Zhong, X Liu, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction. Organic Lett, 2016;18(15):3546-3549. (IF2021 6.072)

26. X Li, J Su, Z Liu, Y Zhu, Z Dong, S Qiu, J Wang, L Lin, Z Shen, Wenjin Yan*, Kairong Wang*, Rui Wang*, Synthesis of Chiral α-Trifluoromethylamines with 2, 2,2-Trifluoroethylamine asa ‘Building Block’. Organic Lett., 2016;18(5):956-959. (IF2021 6.072)

27. Kairong Wang, F Jia , W Dang, Y Zhao, R Zhu, M Sun, S Qiu, X An, Z Ma, Y Zhu, J Yan, Z Kong, Wenjin Yan* , Rui Wang*. Antifungal effect and action mechanism of antimicrobial peptide polybia-CP.  J Pept Sci., 2016;22(1):28-35.

28. Y Zhu, X Li, Q Chen, J Su, F Jia, S Qiu, M Ma, Q Sun, Wenjin Yan*, Kairong Wang*, Rui Wang*, Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-containing Chromanes. Organic Lett., 2015;17(15): 3826-3829. (IF2021 6.072)

29. Q Sun, X Li, J Su, L Zhao, M Ma, Y Zhu, Y Zhao, R Zhu, Wenjin Yan*, Kairong Wang*, Rui Wang. The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5'-Trifluoromethyl-spiro[pyrrolidin-3,2'-oxindoles]. Advanced Synthesis & Catalysis, 2015;357(14-15):3187-3196. (IF2021 5.981)

30. M Ma, Y Zhu, Q Sun, X Li, J Su, L Zhao, Y Zhao, S Qiu, Wenjin Yan*, Kairong Wang*, Rui Wang*. The Asymmetric Synthesis of CF3- containing Spiro[pyrrolidin-3,2’-oxindole] through the Organocatalytic 1, 3-dipolar Cycloaddition Reaction. Chem. Comm.，2015;51(42):8789-8792. (IF2021 6.065)

31. Kairong Wang, W Dang, J Xie, R Zhu, M Sun, F Jia, Y Zhao, X An, S Qiu, X Li, Z Ma, Wenjin Yan*, Rui Wang*. Antimicrobial peptide protonectin disturbs the membrane integrity andinduces ROS production in yeast cells，Biochimica et Biophysica Acta-Biomembranes. 2015;1848(10):2365-2373.

32. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 56：22-29.

33. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrob. Agents Chemother., 2013,57(10), 4632–9. (IF2021 5.938)

34. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88.

35. J Yan¹, Kairong Wang¹, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (IF2021 5.938)

36. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. (IF2021 5.938)

37. J Yan¹, Kairong Wang¹, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie 2012,94 184-191.

38. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33.

39. B Zhang¹, Kai-rong Wang¹, W Zhang, J Yan, J Song, Rui Wang. In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573.

40. Kairong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett., 2009, 278,65-72. (IF2021 9.756)

41. Kairong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett., 2008,268,38-45. (IF2021 9.756)

42. Kairong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8.